Neurological soft signs are not "soft" in brain structure and functional networks: Evidence from ALE meta-analysis

Q Zhao; Z Li; J Huang; C Yan; P Dazzan; C Pantelis; EFC Cheung; SSY Lui; RCK Chan

Journal article

Neurological soft signs are not "soft" in brain structure and functional networks: Evidence from ALE meta-analysis

Q Zhao, Z Li, J Huang, C Yan, P Dazzan, C Pantelis, EFC Cheung, SSY Lui, RCK Chan

Schizophrenia Bulletin | Published : 2014

DOI: 10.1093/schbul/sbt063

Abstract

Background: Neurological soft signs (NSS) are associated with schizophrenia and related psychotic disorders. NSS have been conventionally considered as clinical neurological signs without localized brain regions. However, recent brain imaging studies suggest that NSS are partly localizable and may be associated with deficits in specific brain areas. Method: We conducted an activation likelihood estimation meta-analysis to quantitatively review structural and functional imaging studies that evaluated the brain correlates of NSS in patients with schizophrenia and other psychotic disorders. Six structural magnetic resonance imaging (sMRI) and 15 functional magnetic resonance imaging (fMRI) stud..

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University of Melbourne Researchers

Christos Pantelis Author

Related Projects (3)

EMERGING MENTAL DISORDERS IN YOUNG PEOPLE: USING CLINICAL STAGING FOR PREDICTION, PREVENTION AND EARLY INTERVENTION

Mental disorders are a major cause of disability in Australia, especially for young people. We have developed a clinical staging model cover..

EMERGING MENTAL DISORDERS IN YOUNG PEOPLE: USING CLINICAL STAGING FOR PREDICTION, PREVENTION AND EARLY INTERVENTION

Mental disorders are a major cause of disability in Australia, especially for young people. We have developed a clinical staging model cover..

RESEARCH FELLOWSHIP - PROF CHRISTOS PANTELIS

I have established and head the Melbourne Neuropsychiatry Centre within the University of Melbourne. My university position is a research ch..

Grants

Awarded by National Science Fund China Outstanding Investigator Award

Awarded by National Key Technologies RD Programme

Awarded by Knowledge Innovation Project of the Chinese Academy of Sciences

Awarded by National Health and Medical Research Council Senior Principal Research Fellowship

Awarded by National Health and Medical Research Council Program Grant

Funding Acknowledgements

National Science Fund China Outstanding Investigator Award (81088001 to R. C. K. C.); National Key Technologies R&D Programme (2012BAI36B01 to R. C. K. C.); Key Laboratory of Mental Health; Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-EW-J-8 to R. C. K. C.); National Alliance for Research on Schizophrenia and Depression (to P. D.); National Health and Medical Research Council Senior Principal Research Fellowship (628386 to C. P.); National Alliance for Research on Schizophrenia and Depression Distinguished Investigator Award (to C. P.); National Health and Medical Research Council Program Grant (566529 to C.P.).